Cryptic crossword clue
Rube, dunce men ragged without hindrance 12

The most common and most likely answer to this crossword clue is the 12 letter word UNENCUMBERED

U
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Buddy explains!

The straight part
We know that "without hindrance" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case without hindrance = unencumbered.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNENCUMBERED mean?

UNENCUMBERED adjective
  1. Not burdened with worries, cares or responsibilities.
  2. Free of encumbrance.
  3. (of property) Not subject to any claims.

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