Cryptic crossword clue
Rubs in preparation of best old cream 10

The most common and most likely answer to this crossword clue is the 10 letter word EMBROCATES

E
M
B
R
O
C
A
T
E
S

Buddy explains!

The straight part
We know that "Rubs in" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case rubs in = embrocates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EMBROCATES mean?

EMBROCATES verb
  1. To moisten and rub (a diseased part) with a liquid substance, as with spirit, oil, etc., by means of a cloth or sponge.

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