The most common and most likely answer to this crossword clue is the 6 letter word ANNOYS
I've seen this crossword clue in The Daily Telegraph
A
N
N
O
Y
S
More clues leading to the result ANNOYS
- Hacks off announcing a report, for example
- Sent back section of glossy on nasty bugs
- A racket, say, and what it does
- A din that’s audible is irritating
- Ruffles making a nasty sound, audibly
- A public talk over the airwaves is a source of vexation…
- Needles speakers that don’t start
- Something loud audibly grates
- Bothers listening to a sound
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ANNOYS mean?
ANNOYS noun- A feeling of discomfort or vexation caused by what one dislikes.
- That which causes such a feeling.
- To disturb or irritate, especially by continued or repeated acts; to bother with unpleasant deeds.
- To do something to upset or anger someone; to be troublesome.
- To molest; to harm; to injure.