Cryptic crossword clue
Rule about little room at first needing scrubbing 12

The most common and most likely answer to this crossword clue is the 12 letter word CANCELLATION

I've seen this crossword clue in The Guardian
C
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CANCELLATION mean?

CANCELLATION noun
  1. The act, process, or result of cancelling; as, the cancellation of certain words in a contract, or of the contract itself.
  2. The operation of striking out common factors, in both the dividend and divisor.
  3. A postmark that marks a postage stamp so as to prevent its reuse.
  4. In United States intellectual property law, a proceeding in which an interested party seeks to cancel the registration of a trademark or patent.
  5. The property of being cancellate.

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