Cryptic crossword clue
Run across again, never returning in opposite direction 2-9

The most common and most likely answer to this crossword clue is the 2 letter word RE

I've seen this crossword clue in The Times
R
E


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The straight part
We know that "Run across again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case run across again = re.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RE mean?

RE preposition
  1. About, regarding, with reference to; especially in letters, documents and emails.
RE noun
  1. A syllable used in solfège to represent the second note of a major scale.
RE noun
  1. Reinsurance.

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