Cryptic crossword clue
Run railway to increase efficiency 10

The most common and most likely answer to this crossword clue is the 10 letter word STREAMLINE

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Buddy explains!

The straight part
We know that "to increase efficiency" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to increase efficiency = streamline.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STREAMLINE mean?

STREAMLINE noun
  1. A line that is tangent to the velocity of flow of a fluid; equivalent to the path of a specific particle in that flow.
  2. On a weather chart, a line that is tangent to the flow of the wind.
STREAMLINE verb
  1. To design and construct the contours of a vehicle etc. so as to offer the least resistance to its flow through a fluid.
  2. (by extension) To simplify or organize a process in order to increase its efficiency.
  3. To modernise.

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