The most common and most likely answer to this crossword clue is the 3 plus 2 letter word USE UP
I've seen this crossword clue in The Guardian
U
S
E
U
P
More clues leading to the result USE UP
- Exhaust American power restraining group of countries
- Washington-Brussels summit on peace to finish
- Run through museum unclothed, ending in shop
- Go through group of countries, probing distinctive feature
- Wear out of habit at college
- Finish employment at university
- Exhaust advice on employment of umbrellas
- Need animated film to finish
- Squander advantage for promoting product around Europe
- America finished importing European sap
Buddy explains!

The straight part
We know that "Run through" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case run through = use up.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.