Cryptic crossword clue
Running nude in street, not giving a hoot 12

The most common and most likely answer to this crossword clue is the 12 letter word UNINTERESTED

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "not giving a hoot" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not giving a hoot = uninterested.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNINTERESTED mean?

UNINTERESTED adjective
  1. Unmotivated by personal interest; unbiased, disinterested.
  2. Not interested; indifferent, not concerned.

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