The most common and most likely answer to this crossword clue is the 6 letter word GORING
I've seen this crossword clue in The Daily Telegraph
G
O
R
I
N
G
More clues leading to the result GORING
Buddy explains!

The straight part
We know that "Running through" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case running through = goring.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GORING mean?
GORING verb- (of an animal) To pierce with the horn.
- To pierce with anything pointed, such as a spear.
- To cut in a triangular form.
- To provide with a gore.
- The act by which something is gored; a wound inflicted by a horn, usually the horn of a bull in the context of bullfighting
- A piece of cloth cut diagonally to increase its apparent width.
- Cut gradually sloping, so as to be broader at the clew than at the earing of a sail.