The most common and most likely answer to this crossword clue is the 14 letter word ADMINISTRATION
I've seen this crossword clue in The Guardian
A
D
M
I
N
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S
T
R
A
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N
More clues leading to the result ADMINISTRATION
- Government bill pint-sized Republican put in post
- Running off isn’t held in high regard
- Notice car on street before helping management
- Running wild isn’t held in high esteem
- A Martini stirred finally? No it’s shaken as a rule
- Government, in disarray, isn’t being held in high regard
- Running commercial vehicles on initially tight allowance
- Praise all around isn’t surprising for executive
- Government isn't exactly held in high regard
Buddy explains!

The straight part
We know that "Running" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case running = administration.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ADMINISTRATION mean?
ADMINISTRATION noun- The act of administering; government of public affairs; the service rendered, or duties assumed, in conducting affairs; the conducting of any office or employment; direction.
- A body that administers; the executive part of government; the persons collectively who are entrusted with the execution of laws and the superintendence of public affairs; the chief magistrate and his cabinet or council; or the council, or ministry, alone, as in Great Britain.
- The act of administering, or tendering something to another; dispensation.
- Management.
- An arrangement whereby an insolvent company can continue trading under supervision.