Cryptic crossword clue
Runs low joints, and is persistently annoying 7

The most common and most likely answer to this crossword clue is the 8 plus 1 letter word RANKLES  –

I've seen this crossword clue in The Sunday Telegraph
R
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Buddy explains!

The straight part
We know that "is persistently annoying" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case is persistently annoying = rankles  –.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RANKLES  – mean?

RANKLES  – verb
  1. To cause irritation or deep bitterness.
  2. To fester.

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