The most common and most likely answer to this crossword clue is the 5 letter word PETER
P
E
T
E
R
More clues leading to the result PETER
- Queen follows favourite saint
- Pan perhaps necessary for recipe — teriyaki?
- Great Russian ruler, favourite with our sovereign
- Boy trapped back in concrete pillar
- Fellow safe till down under
- A form of examination including T-cell?
- Piper, perhaps noble, keeping time
- Pop into safe neighbourhood, primarily for type of collar
- Saintly gatekeeper‘s famous rabbit
- Treasure about to be returned to safe
Buddy explains!

The straight part
We know that "Safe" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case safe = peter.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PETER mean?
PETER noun- The penis.
- A safe.
- (most often used in the phrase peter out) To dwindle; to trail off; to diminish to nothing.
- In whist, to play a blue peter.