Cryptic crossword clue
Sailors coming to American city where saint was born 6

The most common and most likely answer to this crossword clue is the 6 letter word TARSUS

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Buddy explains!

The straight part
We know that "city where saint was born" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case city where saint was born = tarsus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TARSUS mean?

TARSUS noun
  1. The part of the foot between the tibia and fibula and the metatarsus.
  2. Any of the seven bones in this part of the foot.
  3. A plate of dense connective tissue found in each eyelid, attached to either the superior tarsal muscle (in the upper eyelid) or inferior tarsal muscle (lower eyelid), which aid with sympathetic control.
  4. In insects and other arthropods, any of a series of articulations in the true foot; the last joint forming the foot in spiders.

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