The most common and most likely answer to this crossword clue is the 8 letter word OPPOSITE
I've seen this crossword clue in The Times
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More clues leading to the result OPPOSITE
- Work place around Post Office counter
- Facing work to advance start of earning
- Sailors putting their heads together plot something very different
- Converse with petty officer in work place
- After surgery, confident 4’s been removed on the other side
- Rival‘s work attitude embraces an indefinable quality
- Facing river in workplace
- Facing put in place after work on back of blouse
- It comes in to resist on the other side
- Facing work, poet is confused
Buddy explains!

The straight part
We know that "something very different" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case something very different = opposite.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OPPOSITE mean?
OPPOSITE noun- Something opposite or contrary to something else.
- An opponent.
- An antonym.
- An additive inverse.
- Located directly across from something else, or from each other.
- Of leaves and flowers, positioned directly across from each other on a stem.
- Facing in the other direction.
- Of either of two complementary or mutually exclusive things.
- Extremely different; inconsistent; contrary; repugnant; antagonistic.
- In an opposite position.
- Facing, or across from.
- In a complementary role to.
- On another channel at the same time.