Cryptic crossword clue
Saint gets end of lance in vital organ 8

The most common and most likely answer to this crossword clue is the 8 letter word PANCREAS

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does PANCREAS mean?

PANCREAS noun
  1. A gland near the stomach which secretes a fluid into the duodenum to help with food digestion. The fluid contains protease, carbohydrase and lipase, which breaks down larger molecules into smaller pieces. The pancreas also produces the hormones insulin and glucagon which regulate blood sugar. These hormones are released into the cardiovascular system.

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