The most common and most likely answer to this crossword clue is the 8 letter word ALOPECIA
I've seen this crossword clue in The Daily Telegraph
A
L
O
P
E
C
I
A
More clues leading to the result ALOPECIA
- Which comes as no shock to those who have it
- Drivers accept police corruption resulting in personal loss
- Shock loss bound to divide a government agency in America
- Salon special not protected repeatedly for loss of hair
- A cut’s the reverse of excellent, entrenching one’s hair problem
- Unwanted falling-out with one having to run anti-crime organisation
- A way of progressing agents’ lack of cover
- Having no locks, bound to get caught by a group spying
- Hair loss bound to follow a spy group
- Bound to be seized by American agents? This eliminates shock
Buddy explains!

The straight part
We know that "loss of hair" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loss of hair = alopecia.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ALOPECIA mean?
ALOPECIA noun- Baldness.
- Deficiency of the hair, which may be caused by failure to grow or loss after growth.
- Loss of hair (especially on the head) or loss of wool or feathers, which either happens naturally or is caused by disease.