Cryptic crossword clue
Sanctimonious setter might be compared to you 6-4-4

The most common and most likely answer to this crossword clue is the 6 letter word HOLIER

I've seen this crossword clue in The Daily Telegraph
H
O
L
I
E
R

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HOLIER mean?

HOLIER adjective
  1. Having, or being full of, holes
HOLIER adjective
  1. Dedicated to a religious purpose or a god.
  2. Revered in a religion.
  3. Morally perfect or flawless, or nearly so.
  4. Separated or set apart from (something unto something or someone else).
  5. Set apart or dedicated for a specific purpose, or for use by a single entity or person.
  6. Used as an intensifier in various interjections.

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