Cryptic crossword clue
Sao Tome’s partner and a backward fool combine for Italian 8 not first

The most common and most likely answer to this crossword clue is the 11 letter word PRINCIPESSA

P
R
I
N
C
I
P
E
S
S
A

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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