The most common and most likely answer to this crossword clue is the 5 letter word NERVE
I've seen this crossword clue in The Times
N
E
R
V
E
More clues leading to the result NERVE
- Sauce bottle?
- Message sensibly delivered in this bottle?
- Courage of owner finally entering flat that's been turned over
- French author switching couple of characters shows courage
- Bottle comes in plainer version
- New First Lady possesses rare self-confidence
- Polar opposite to start work in shop, showing bravery
- Sauce bottle
- Bottle perhaps attached to optic?
- Cool person holds it, never flustered
Buddy explains!

The straight part
We know that "Sauce/bottle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sauce/bottle = nerve.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does NERVE mean?
NERVE noun- A bundle of neurons with their connective tissue sheaths, blood vessels and lymphatics.
- A neuron.
- A vein in a leaf; a grain in wood
- Courage, boldness.
- Patience.
- Stamina, endurance, fortitude.
- Audacity, gall.
- (polymer technology) The elastic resistance of raw rubber or other polymers to permanent deformation during processing.
- (in the plural) Agitation caused by fear, stress or other negative emotion.
- Sinew, tendon.
- To give courage.
- To give strength; to supply energy or vigour.