The most common and most likely answer to this crossword clue is the 11 letter word CHOLESTEROL
I've seen this crossword clue in The Times
C
H
O
L
E
S
T
E
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O
L
More clues leading to the result CHOLESTEROL
- School banning son about boy offering harmful substance?
- What shifts fat? Tight clothes and active role
- Potentially dodgy stuff in the claret left lechers too sozzled
- Unruly troll chose to embrace energy level many would seek to lower
- Old lecturer probing part of body and learning about source of blockage?
- Lets her cool off — it may cause problems of the heart
- It could be risky when high escort tottering around chamber gets a little loud
Buddy explains!
The straight part
We know that "harmful substance?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case harmful substance? = cholesterol.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CHOLESTEROL mean?
CHOLESTEROL noun- A sterol lipid synthesized by the liver and transported in the bloodstream to the membranes of all animal cells; it plays a central role in many biochemical processes and, as a lipoprotein that coats the walls of blood vessels, is associated with cardiovascular disease.
- The level of cholesterol in the body.