Cryptic crossword clue
Scientific pioneer, 50, appearing in long film 9

The most common and most likely answer to this crossword clue is the 9 letter word ALCHEMIST

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Buddy explains!

The straight part
We know that "Scientific pioneer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case scientific pioneer = alchemist.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ALCHEMIST mean?

ALCHEMIST noun
  1. One who practices alchemy.
  2. One who blends material or substances in the nature or supposed nature of alchemy.

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