Cryptic crossword clue
Scot's pretty heartless, certainly not fed up! 4

The most common and most likely answer to this crossword clue is the 4 letter word BONY

I've seen this crossword clue in The Times
B
O
N
Y

Buddy explains!

The straight part
We know that "certainly not fed up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case certainly not fed up = bony.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BONY mean?

BONY adjective
  1. Resembling, having the appearance or consistence of, or relating to bone; osseous.
  2. Full of bones
  3. With little flesh; skinny, thin
  4. Having prominent bones

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