Cryptic crossword clue
Screw top of jar I dropped into real mess 6

The most common and most likely answer to this crossword clue is the 6 letter word JAILER

I've seen this crossword clue in The Times
J
A
I
L
E
R

Buddy explains!

The straight part
We know that "Screw" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case screw = jailer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does JAILER mean?

JAILER noun
  1. One who enforces confinement in a jail or prison.

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