The most common and most likely answer to this crossword clue is the 5 letter word QUALM
I've seen this crossword clue in The Times
Q
U
A
L
M
More clues leading to the result QUALM
Buddy explains!

The straight part
We know that "Scruple/Scruple" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case scruple/scruple = qualm.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does QUALM mean?
QUALM noun- A feeling of apprehension, doubt, fear etc.
- A sudden sickly feeling; queasiness.
- A prick of the conscience; a moral scruple, a pang of guilt. (Now often in negative constructions.)
- Mortality; plague; pestilence.
- A calamity or disaster.
- To have a sickly feeling.