Cryptic crossword clue
Sea Eagle follows Little Cloud, initially over posh Swiss city 7

The most common and most likely answer to this crossword clue is the 7 letter word LUCERNE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Swiss city" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case swiss city = lucerne.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LUCERNE mean?

LUCERNE noun
  1. Alfalfa.

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