The most common and most likely answer to this crossword clue is the 6 letter word PUFFER
I've seen this crossword clue in The Times
P
U
F
F
E
R
More clues leading to the result PUFFER
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The straight part
We know that "fish" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fish = puffer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PUFFER mean?
PUFFER noun- Someone or something that puffs.
- Any of several poisonous fish, of the family Tetraodontidae, which have the ability to inflate their bodies when in danger.
- A manually-operated inhaler.
- A train; a locomotive, usually one that is steam-powered.
- A Clyde puffer, a kind of small ship.
- A car left idling to warm up, emitting steam from the rear.
- An insulated puffy jacket, such as a down jacket.
- A person who gives exaggerated praise to a product, literary work, etc.
- One who is employed by the owner or seller of goods sold at auction to bid up the price; a by-bidder.
- An alchemist; so named from their constant attendance to the bellows of their furnaces.
- The common, or harbour, porpoise.
- A kier used in dyeing.
- A soffietta.
- A finite pattern that moves like a spaceship but leaves a trail of debris.