The most common and most likely answer to this crossword clue is the 8 plus 7 letter word ANABOLIC STEROID
A
N
A
B
O
L
I
C
S
T
E
R
O
I
D
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.