Cryptic crossword clue
Second royal in unpleasant house, a single-sex one 9

The most common and most likely answer to this crossword clue is the 9 letter word MONASTERY

I've seen this crossword clue in The Guardian
M
O
N
A
S
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Y


Buddy explains!

The straight part
We know that "house, a single-sex one" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case house, a single-sex one = monastery.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MONASTERY mean?

MONASTERY noun
  1. Building for housing monks or others who have taken religious vows

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