Cryptic crossword clue
Secret Intelligence Service upholds instruction to reader with drooping eyelids 6

The most common and most likely answer to this crossword clue is the 6 letter word PTOSIS

P
T
O
S
I
S


Buddy explains!

The straight part
We know that "drooping eyelids" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drooping eyelids = ptosis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PTOSIS mean?

PTOSIS noun
  1. The prolapse of a bodily organ, especially drooping of the eyelid or the breasts.

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