The most common and most likely answer to this crossword clue is the 1 letter word D
D
Buddy explains!

The straight part
We know that "See 25A" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case see 25a = hand.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does D mean?
D adjective- Abbreviation of declare.
- From a higher position to a lower one; downwards.
- At a lower or further place or position along a set path.
- South (as south is at the bottom of typical maps).
- Away from the city (regardless of direction).
- At or towards any place that is visualised as 'down' by virtue of local features or local convention, or arbitrarily, irrespective of direction or elevation change.
- Towards the opponent's side (in ball-sports).
- Into a state of non-operation.
- To a subordinate or less prestigious position or rank.
- In the direction leading away from the principal terminus, away from milepost zero.
- (sentence substitute) Get down.
- (academia) Away from Oxford or Cambridge.
- From a remoter or higher antiquity.
- So as to lessen quantity, level or intensity.
- So as to reduce size, weight or volume.
- From less to greater detail.
- So as to secure or compress something to the floor, ground, or other (usually horizontal) surface.
- (intensifier) Used with verbs to add emphasis to the action of the verb.
- Used with verbs to indicate that the action of the verb was carried to some state of completion, rather than being of indefinite duration.