Cryptic crossword clue
See live part of brain

The most common and most likely answer to this crossword clue is the 4 letter word LOBE

I've seen this crossword clue in Independent
L
O
B
E


Buddy explains!

The straight part
We know that "part of brain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case part of brain = lobe.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LOBE mean?

LOBE noun
  1. Any projection or division, especially one of a somewhat rounded form.
  2. A clear division of an organ that can be determined at the gross anatomy level, especially one of the parts of the brain, liver or lung.
  3. A semicircular pattern left on the ice as the skater travels across it.

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