Cryptic crossword clue
Seeds coming from small openings in the skin

The most common and most likely answer to this crossword clue is the 6 letter word SPORES

I've seen this crossword clue in The Guardian
S
P
O
R
E
S

Buddy explains!

The straight part
We know that "Seeds" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case seeds = spores.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SPORES mean?

SPORES noun
  1. A reproductive particle, usually a single cell, released by a fungus, alga, or plant that may germinate into another.
  2. A thick resistant particle produced by a bacterium or protist to survive in harsh or unfavorable conditions.
SPORES verb
  1. To produce spores.

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