Cryptic crossword clue
Seizure in cardiac tissue unsettles surgeon initially

The most common and most likely answer to this crossword clue is the 7 plus 5 letter word INCTUS  ICTUS

I've seen this crossword clue in Independent
I
N
C
T
U
S
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I
C
T
U
S

Buddy explains!

The straight part
We know that "Seizure" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case seizure = inctus  ictus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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