The most common and most likely answer to this crossword clue is the 8 letter word MILANESE
I've seen this crossword clue in Financial Times
M
I
L
A
N
E
S
E
More clues leading to the result MILANESE
- Italian citizens coming from same line somehow
- Seminal works on European from Italy
- Italian city’s major road leading to minor roads east
- Italian name lies in tatters
- Italian enamel is used imaginatively
- Italian road during depression lacking transport system
- From an Italian city, motorway leading to roads east
Buddy explains!
The straight part
We know that "from Italy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case from italy = milanese.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.