The most common and most likely answer to this crossword clue is the 11 letter word FORMICATION
I've seen this crossword clue in The Guardian
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does FORMICATION mean?
FORMICATION noun- An abnormal skin sensation similar to that of insects crawling over or within the skin; a tactile hallucination involving such a sensation. A common side-effect of substance abuse, it can also be experienced with high fever, menopause, skin cancer, diabetic neuropathy, or herpes zoster.