Cryptic crossword clue
Sense organ on mushroom atop hill 8

The most common and most likely answer to this crossword clue is the 8 letter word RECEPTOR

I've seen this crossword clue in Financial Times
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More clues leading to the result RECEPTOR

Buddy explains!

The straight part
We know that "Sense organ" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sense organ = receptor.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RECEPTOR mean?

RECEPTOR noun
  1. A protein on a cell wall that binds with specific molecules so that they can be absorbed into the cell in order to control certain functions.
  2. Any specialized cell or structure that responds to sensory stimuli.

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