Cryptic crossword clue
Separate river drying up before the end 5

The most common and most likely answer to this crossword clue is the 5 letter word SEVER

I've seen this crossword clue in The Guardian
S
E
V
E
R

Buddy explains!

The straight part
We know that "Separate" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case separate = sever.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEVER mean?

SEVER verb
  1. To cut free.
  2. To suffer disjunction; to be parted or separated.
  3. To make a separation or distinction; to distinguish.
  4. To disunite; to disconnect; to terminate.

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