Cryptic crossword clue
Separation of state and religion curses Mali after Reformation 10

The most common and most likely answer to this crossword clue is the 10 letter word SECULARISM

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Buddy explains!

The straight part
We know that "Separation of state and religion" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case separation of state and religion = secularism.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SECULARISM mean?

SECULARISM noun
  1. Neutrality towards all religions.
  2. The political belief in the separation of church and state, i.e. the position that religious belief should not influence public and governmental decisions.

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