Cryptic crossword clue
Serial criminal on protest to cause depression 10

The most common and most likely answer to this crossword clue is the 10 letter word DEMORALISE

I've seen this crossword clue in The Daily Telegraph
D
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The cryptic/wordplay part
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What does DEMORALISE mean?

DEMORALISE verb
  1. To destroy the morale of; to dishearten.

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