Cryptic crossword clue
Service area with major retail chain strikes out 12

The most common and most likely answer to this crossword clue is the 12 letter word COUNTERMANDS

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Buddy explains!

The straight part
We know that "strikes out" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case strikes out = countermands.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does COUNTERMANDS mean?

COUNTERMANDS verb
  1. To revoke (a former command); to cancel or rescind by giving an order contrary to one previously given.
  2. To recall a person or unit with such an order.
  3. To prohibit.
  4. To oppose; to revoke the command of.

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