The most common and most likely answer to this crossword clue is the 5 letter word LURGY
I've seen this crossword clue in The Times
L
U
R
G
Y
Buddy explains!

The straight part
We know that "bug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bug = lurgy.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LURGY mean?
LURGY noun- A fictitious, highly infectious disease; often used in the phrase "the dreaded lurgi", sometimes as a reference to flu-like symptoms
- Any uncategorised disease with symptoms similar to a cold or flu that renders one unable to work.