Cryptic crossword clue
Set against trifle having turned sour 4,3

The most common and most likely answer to this crossword clue is the 4 plus 3 letter word PLAY OFF

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Buddy explains!

The straight part
We know that "Set against" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case set against = play off.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PLAY OFF mean?

PLAY OFF noun
  1. A final game in a series needed to break a tie.
  2. A short series of games to select a league champion.

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