The most common and most likely answer to this crossword clue is the 6 plus 4 letter word FLIGHT PLAN
F
L
I
G
H
T
P
L
A
N
Buddy explains!
The straight part
We know that "course of journey" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case course of journey = flight plan.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.