Cryptic crossword clue
Set of 45s, maybe, but no new instruments 4

The most common and most likely answer to this crossword clue is the 4 letter word UKES

I've seen this crossword clue in The Times
U
K
E
S

Buddy explains!

The straight part
We know that "instruments" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instruments = ukes.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UKES mean?

UKES noun
  1. The training partner against whom tori performs a move.
  2. (Japanese fiction) A passive or submissive male fictional character in a same-sex relationship; a bottom.
UKES noun
  1. A small four-stringed guitar.

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