Cryptic crossword clue
Set up and clued up about mess up 8

The most common and most likely answer to this crossword clue is the 8 letter word ASSEMBLE

I've seen this crossword clue in The Guardian
A
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Buddy explains!

The straight part
We know that "Set up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case set up = assemble.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASSEMBLE mean?

ASSEMBLE verb
  1. To put together.
  2. To gather as a group.
  3. To translate from assembly language to machine code

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