Cryptic crossword clue
Set up regulation about drug producing mark on skin 4

The most common and most likely answer to this crossword clue is the 4 letter word WEAL

I've seen this crossword clue in The Guardian
W
E
A
L


Buddy explains!

The straight part
We know that "mark on skin" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mark on skin = weal.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WEAL mean?

WEAL noun
  1. Wealth, riches.
  2. Welfare, prosperity.
  3. (by extension) Boon, benefit.
  4. Specifically, the general happiness of a community, country etc. (often with qualifying word).
WEAL noun
  1. A raised, longitudinal wound, usually purple, on the surface of flesh caused by a stroke of a rod or whip; a welt.
WEAL verb
  1. To mark with stripes; to wale.

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