Cryptic crossword clue
Set up sweetheart following accident pinching bottom 10

The most common and most likely answer to this crossword clue is the 10 letter word PREARRANGE

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The straight part
We know that "Set up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case set up = prearrange.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PREARRANGE mean?

PREARRANGE verb
  1. To arrange in advance.

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