Cryptic crossword clue
Sets off to make appointments around school 9

The most common and most likely answer to this crossword clue is the 9 letter word DETONATES

I've seen this crossword clue in Financial Times
D
E
T
O
N
A
T
E
S

Buddy explains!

The straight part
We know that "Sets off" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sets off = detonates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DETONATES mean?

DETONATES verb
  1. To explode; to blow up. Specifically, to combust supersonically via shock compression.
  2. To cause to explode.

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