Cryptic crossword clue
Setter requesting a ride, say, is shot in the arm 4-2-2

The most common and most likely answer to this crossword clue is the 10 letter word PICK-ME-UP

P
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Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PICK-ME-UP mean?

PICK-ME-UP noun
  1. A drink, especially an alcoholic one, taken as a stimulant or sometimes as a hangover cure; a restorative, tonic or bracer.

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