Cryptic crossword clue
Setter’s dropping weight initially, so I hope that’s shifted 8

The most common and most likely answer to this crossword clue is the 8 letter word WHOOPSIE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Setter’s dropping" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case setter’s dropping = whoopsie.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WHOOPSIE mean?

WHOOPSIE noun
  1. A piece of excrement.
  2. A homosexual man, especially one who has camp mannerisms.

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